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ΟΡΙΣΜΟΣ: Κοκκίωμα είναι μια απάντηση του ανοσοποιητικού συστήματος ,που συμβαίνει όταν τα μακροφάγα (κύτταρα που συμβάλλουν στην άμυνα του οργανισμού) αδυνατούν να καταστρέψουν ξένες ουσίες που έχουν εισβάλει στους ιστούς του οργανισμού (όπως μικρόβια ,χειρουργικά εργαλεία κ.α.)
Εμφανίζονται συχνά σε παθήσεις όπως λέπρα ,φυματίωση και ορισμένες μυκητιάσεις.